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mfg e8 levels (Boster Bio)

Name: mfg e8 levels
Brand: Boster Bio
Rating: 93 (6 reviews)

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Boster Bio mfg e8 levels
Mfg E8 Levels, supplied by Boster Bio, used in various techniques. Bioz Stars score: 93/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 6 article reviews

mfg e8 levels - by Bioz Stars, 2026-02

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Serum MFG-E8 levels in patients with liver diseases. Serum milk fat globule-EGF factor 8 (MFG-E8) levels are shown for healthy volunteers (HVs) and hepatocellular carcinoma (HCC) patients ( A ), for HCC patients stratified by tumor size ( B ) by etiology of liver diseases ( C ), for hepatitis B virus (HBV)-infected, hepatitis C virus (HCV)-infected, post-sustained virologic response (SVR) and non-alcoholic fatty liver disease (NAFLD) patients with chronic hepatitis (CH), liver cirrhosis (LC), and HCCs ( D ), and in patients with benign liver tumors (Benign), intrahepatic cholangiocarcinoma (ICC), or metastatic liver tumors derived from primary colon cancer (Meta) ( D ) and for HCC patients before and after surgery (solid line, n = 12) or radiofrequency ablation (dashed line, n = 7) ( E ). Box plots represent the interquartile range and whiskers show minimum and maximum values. The line in each box shows the median. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, † p < 0.0001 compared with HV by Kruskal-Wallis test with Dunn’s multiple comparison test. Paired Student’s t test was used for the analysis presented in ( E ).

Journal: Scientific Reports

Article Title: Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma

doi: 10.1038/s41598-019-52356-6

Figure Lengend Snippet: Serum MFG-E8 levels in patients with liver diseases. Serum milk fat globule-EGF factor 8 (MFG-E8) levels are shown for healthy volunteers (HVs) and hepatocellular carcinoma (HCC) patients ( A ), for HCC patients stratified by tumor size ( B ) by etiology of liver diseases ( C ), for hepatitis B virus (HBV)-infected, hepatitis C virus (HCV)-infected, post-sustained virologic response (SVR) and non-alcoholic fatty liver disease (NAFLD) patients with chronic hepatitis (CH), liver cirrhosis (LC), and HCCs ( D ), and in patients with benign liver tumors (Benign), intrahepatic cholangiocarcinoma (ICC), or metastatic liver tumors derived from primary colon cancer (Meta) ( D ) and for HCC patients before and after surgery (solid line, n = 12) or radiofrequency ablation (dashed line, n = 7) ( E ). Box plots represent the interquartile range and whiskers show minimum and maximum values. The line in each box shows the median. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, † p < 0.0001 compared with HV by Kruskal-Wallis test with Dunn’s multiple comparison test. Paired Student’s t test was used for the analysis presented in ( E ).

Article Snippet: Serum MFG-E8 levels were measured using an ELISA kit (DFGE80; R&D Systems, Minneapolis, MN, USA) according to the manufacturer’s instructions.

Techniques: Virus, Infection, Derivative Assay, Comparison

ROC analyses of serum MFG-E8, AFP, and DCP levels and our prediction model for diagnosis of HCC patients. ( A ) Receiver operating characteristic (ROC) curves for distinguishing hepatocellular carcinoma (HCC) patients (n = 185) from chronic hepatitis (CH)/ liver cirrhosis (LC) patients (n = 108). The optimal cutoff value for milk fat globule-EGF factor 8 (MFG-E8) was determined as those yielding the minimal value for (1 − sensitivity) 2 + (1 − specificity) 2 . ( B ) Venn diagram presenting the distribution of HCC patients according to MFG-E8, α-fetoprotein (AFP), and des-γ-carboxy prothrombin (DCP). ( C,D ) Performance assessment of our prediction model and other HCC tumor biomarkers for HCC for distinguishing HCC patients (n = 185) from CH/LC patients (n = 108) ( C ), and patients with HCCs smaller than 3 cm (n = 77) from CH/LC patients (n = 108) ( D ). AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value.

Journal: Scientific Reports

Article Title: Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma

doi: 10.1038/s41598-019-52356-6

Figure Lengend Snippet: ROC analyses of serum MFG-E8, AFP, and DCP levels and our prediction model for diagnosis of HCC patients. ( A ) Receiver operating characteristic (ROC) curves for distinguishing hepatocellular carcinoma (HCC) patients (n = 185) from chronic hepatitis (CH)/ liver cirrhosis (LC) patients (n = 108). The optimal cutoff value for milk fat globule-EGF factor 8 (MFG-E8) was determined as those yielding the minimal value for (1 − sensitivity) 2 + (1 − specificity) 2 . ( B ) Venn diagram presenting the distribution of HCC patients according to MFG-E8, α-fetoprotein (AFP), and des-γ-carboxy prothrombin (DCP). ( C,D ) Performance assessment of our prediction model and other HCC tumor biomarkers for HCC for distinguishing HCC patients (n = 185) from CH/LC patients (n = 108) ( C ), and patients with HCCs smaller than 3 cm (n = 77) from CH/LC patients (n = 108) ( D ). AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value.

Article Snippet: Serum MFG-E8 levels were measured using an ELISA kit (DFGE80; R&D Systems, Minneapolis, MN, USA) according to the manufacturer’s instructions.

Techniques:

The relationship between serum preoperative MFG-E8 levels and HCC recurrence or survival following hepatectomy. ( A ) Kaplan–Meier analysis of overall survival (OS) for patients stratified by early recurrence (ER) within 1 year of resection (n = 54) and no recurrence within 1 year of resection (n = 131). ( B ) Serum milk fat globule-EGF factor 8 (MFG-E8) levels for preoperative hepatocellular carcinoma (HCC) patients grouped by early recurrence (ER; n = 54), late recurrence (LR; n = 52), and no recurrence (NR; n = 79). (C,D) Kaplan–Meier analysis of disease free survival (DFS) ( C ) and overall survival (OS) ( D ) for HCC patients stratified by serum MFG-E8 levels (cut-off: 3.42 ng/mL). Box plots show the interquartile range and whiskers show the minimum and maximum values. The line in each box shows the median. *p < 0.05.

Journal: Scientific Reports

Article Title: Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma

doi: 10.1038/s41598-019-52356-6

Figure Lengend Snippet: The relationship between serum preoperative MFG-E8 levels and HCC recurrence or survival following hepatectomy. ( A ) Kaplan–Meier analysis of overall survival (OS) for patients stratified by early recurrence (ER) within 1 year of resection (n = 54) and no recurrence within 1 year of resection (n = 131). ( B ) Serum milk fat globule-EGF factor 8 (MFG-E8) levels for preoperative hepatocellular carcinoma (HCC) patients grouped by early recurrence (ER; n = 54), late recurrence (LR; n = 52), and no recurrence (NR; n = 79). (C,D) Kaplan–Meier analysis of disease free survival (DFS) ( C ) and overall survival (OS) ( D ) for HCC patients stratified by serum MFG-E8 levels (cut-off: 3.42 ng/mL). Box plots show the interquartile range and whiskers show the minimum and maximum values. The line in each box shows the median. *p < 0.05.

Article Snippet: Serum MFG-E8 levels were measured using an ELISA kit (DFGE80; R&D Systems, Minneapolis, MN, USA) according to the manufacturer’s instructions.

Techniques:

Correlation between serum MFG-E8 level and clinicopathological features in 185 HCC patients.

Journal: Scientific Reports

Article Title: Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma

doi: 10.1038/s41598-019-52356-6

Figure Lengend Snippet: Correlation between serum MFG-E8 level and clinicopathological features in 185 HCC patients.

Article Snippet: Serum MFG-E8 levels were measured using an ELISA kit (DFGE80; R&D Systems, Minneapolis, MN, USA) according to the manufacturer’s instructions.

Techniques:

Factors associated with early recurrence after hepatectomy for HCC (n = 185).

Journal: Scientific Reports

Article Title: Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma

doi: 10.1038/s41598-019-52356-6

Figure Lengend Snippet: Factors associated with early recurrence after hepatectomy for HCC (n = 185).

Article Snippet: Serum MFG-E8 levels were measured using an ELISA kit (DFGE80; R&D Systems, Minneapolis, MN, USA) according to the manufacturer’s instructions.

Techniques:

Factors associated with overall survival after hepatectomy for HCC (n = 185).

Journal: Scientific Reports

Article Title: Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma

doi: 10.1038/s41598-019-52356-6

Figure Lengend Snippet: Factors associated with overall survival after hepatectomy for HCC (n = 185).

Article Snippet: Serum MFG-E8 levels were measured using an ELISA kit (DFGE80; R&D Systems, Minneapolis, MN, USA) according to the manufacturer’s instructions.

Techniques:

Serum MFG-E8 levels and EVs in HVs and HCC patients. ( A ) Extracellular vesicles (EVs) isolated using the Tim4 affinity method were analyzed by nanoparticle tracking analysis (NTA) using NanoSight LM10. ( B ) Expression of the EV markers CD63, CD9, CD81 and flotillin 1 by western blotting. Full-length blots are presented in Supplementary Fig. . ( C ) Comparision of serum milk fat globule-EGF factor 8 (MFG-E8) levels before and after EV isolation by the Tim4 affinity method. ( D ) Correlation between serum MFG-E8 levels and the concentration of serum EVs isolated using the Tim4 affinity method. Sera were drawn from healthy volunteers (HVs) (n = 20) and hepatocellular carcinoma (HCC) patients (n = 20). ( E ) Comparative analysis of serum EVs from HVs and HCC patients by NTA. ( F ) EVs isolated using the ultracentrifugation method were analyzed by NTA using NanoSight LM10. ( G ) Comparative analysis of serum EVs isolated by the ultracentrifugation method from HCC patients (n = 15) and HVs (n = 15). *p < 0.05, **p < 0.01, ***p < 0.001 by Kruskal-Wallis test with Dunn’s multiple comparison test.

Journal: Scientific Reports

Article Title: Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma

doi: 10.1038/s41598-019-52356-6

Figure Lengend Snippet: Serum MFG-E8 levels and EVs in HVs and HCC patients. ( A ) Extracellular vesicles (EVs) isolated using the Tim4 affinity method were analyzed by nanoparticle tracking analysis (NTA) using NanoSight LM10. ( B ) Expression of the EV markers CD63, CD9, CD81 and flotillin 1 by western blotting. Full-length blots are presented in Supplementary Fig. . ( C ) Comparision of serum milk fat globule-EGF factor 8 (MFG-E8) levels before and after EV isolation by the Tim4 affinity method. ( D ) Correlation between serum MFG-E8 levels and the concentration of serum EVs isolated using the Tim4 affinity method. Sera were drawn from healthy volunteers (HVs) (n = 20) and hepatocellular carcinoma (HCC) patients (n = 20). ( E ) Comparative analysis of serum EVs from HVs and HCC patients by NTA. ( F ) EVs isolated using the ultracentrifugation method were analyzed by NTA using NanoSight LM10. ( G ) Comparative analysis of serum EVs isolated by the ultracentrifugation method from HCC patients (n = 15) and HVs (n = 15). *p < 0.05, **p < 0.01, ***p < 0.001 by Kruskal-Wallis test with Dunn’s multiple comparison test.

Article Snippet: Serum MFG-E8 levels were measured using an ELISA kit (DFGE80; R&D Systems, Minneapolis, MN, USA) according to the manufacturer’s instructions.

Techniques: Isolation, Expressing, Western Blot, Concentration Assay, Comparison

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